Abstract

Fibromyalgia is musculoskeletal disorder that affect the bones, joints, muscles, and connective tissues throughout the body. The administration of ozone therapy has shown promise in addressing various musculoskeletal disorders by modulating pain and inflammation. Ozone therapy has demonstrated significant therapeutic potential in treating musculoskeletal conditions such as fractures, osteoarthritis, and chronic pain syndromes. Given its anti-inflammatory and pain-relieving properties, ozone therapy holds promise for managing several musculoskeletal disorders. However, concerns about its potential toxicity have been raised in some studies, highlighting the need to follow strict administration protocols to ensure safety. Variability in patient responses and risks associated with oxidizing agents were also noted. This comprehensive review explores the mechanisms, clinical evidence, and potential benefits of ozone therapy in fibromyalgia.